Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNA damage repair: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| PRMT inhibitor | downregulates | drug | 0.90 |
| P53 | regulates | gene | 0.85 |
| TP53 | regulates | gene | 0.80 |
| PRMT4 | regulates | gene | 0.80 |
| protein arginine methylation | modulates | process | 0.75 |
| SIRT6 | participates_in | gene | 0.38 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SIRT6-NAD+ Axis Enhancement Therapy | 0.395 | neurodegeneration | Epigenetic clocks and biological aging i |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.469
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation re [PMID:36593966] | Li B, Xin Z, Gao S, Li Y, Guo S, Fu Y, X | Theranostics | 2023 | 1 |
| Assessing the Status of Mandatory Tuberculosis Case Notification among Private P [PMID:35068738] | Duggal K, Elsy M, Majella MG, Akkilagunt | Indian J Community Med | 2021 | 1 |
| Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic [PMID:33888596] | Yoshino M, Yoshino J, Kayser BD, Patti G | Science | 2021 | 1 |
| Protocol for the Bottom-Up Proteomic Analysis of Mouse Spleen. [PMID:33377090] | Dowling P, Gargan S, Zweyer M, Henry M, | STAR Protoc | 2020 | 1 |
| Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity [PMID:30193097] | Latorre-Muro P, Baeza J, Armstrong EA, H | Mol Cell | 2018 | 1 |
| The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcin [PMID:28329682] | Nargund AM, Pham CG, Dong Y, Wang PI, Os | Cell Rep | 2017 | 1 |
| Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype [PMID:26686024] | Wiley CD, Velarde MC, Lecot P, Liu S, Sa | Cell Metab | 2016 | 1 |
| SIRT6 inhibits intermittent hypoxia-induced lung injury by stabilizing NRF2. [PMID:41478020] | Qin R, Liu Z, Li R, Li Y, Yang Y et al. | Tissue Cell | 2026 | 0 |
| Inflammation-targeted single-atom nanozymes drive microglial depolarization and [PMID:41624511] | Liu B, Xiang C, Zhang X, Guo W, Wu H et | Mater Today Bio | 2026 | 0 |
| Bupleurum chinense ameliorates metabolic-associated fatty liver disease by modul [PMID:41666508] | Liu S, Chen P, Li Y, Pan Z, Zhang C et a | Phytomedicine | 2026 | 0 |
| Deciphering the role of SIRT6 in suppressing the AMPK-mTOR-TFEB axis: regulation [PMID:41957523] | Li CS, Jin H, Meng R, Baek SW, Kim SH et | Cancer Gene Ther | 2026 | 0 |
| SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glut [PMID:41136182] | Zhang M, Chen C, Zhang H, Long T, Wang T | Gut | 2025 | 0 |
| SGK1-Mediated Vascular Smooth Muscle Cell Phenotypic Transformation Promotes Tho [PMID:39633576] | Leng S, Li H, Zhang P, Dang Z, Shao B, X | Arteriosclerosis, thrombosis, | 2025 | 0 |
| On the interface of aging, cancer, and neurodegeneration with SIRT6 and L1 retro [PMID:39251041] | Nahálková J | Ageing research reviews | 2024 | 0 |
| Cartilage-specific Sirt6 deficiency represses IGF-1 and enhances osteoarthritis [PMID:37550003] | Collins JA, Kim CJ, Coleman A, Little A, | Annals of the rheumatic diseas | 2023 | 0 |
| Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegen [PMID:34151764] | Kumar V, Kundu S, Singh A, Singh S | Current neuropharmacology | 2022 | 0 |
| Ergothioneine and its prospects as an anti-ageing compound. [PMID:36244584] | Apparoo Y, Phan CW, Kuppusamy UR, Sabara | Experimental gerontology | 2022 | 0 |
| Cyclosporine modulates neutrophil functions via the SIRT6-HIF-1α-glycolysis axis [PMID:33634990] | Lu H, Lin J, Xu C, Sun M, Zuo K, Zhang X | Clinical and translational med | 2021 | 0 |